An FDA-approved nasal spray for treatment-resistant depression that works on a different pathway in the brain — with improvement possible in as little as 24 hours.
An FDA-approved nasal spray for treatment-resistant depression that works on a different pathway in the brain — with improvement possible in as little as 24 hours.
Spravato® (esketamine) is an FDA-approved nasal spray for adults with treatment-resistant depression. Instead of targeting serotonin like most antidepressants, it acts on glutamate — a different pathway in the brain believed to help restore the connections that depression wears down. That different mechanism is why it can help when other medications haven’t, and why some people notice a shift in as little as 24 hours rather than the weeks traditional antidepressants require. As of 2025, Spravato is the first and only medication of its kind approved to be used on its own for treatment-resistant depression — not only alongside an oral antidepressant.
You spray the medication yourself under supervision. Because Spravato is a controlled medication given through a certified REMS program, every dose happens in our office — never at home.
You'll relax in a quiet, comfortable space while our team monitors you for about two hours after each dose.
You won't be able to drive afterward, so you'll arrange a ride. Treatment is typically twice weekly at first, then tapers as you respond.
Spravato is designed for adults whose depression hasn’t responded adequately to at least two antidepressants. It’s also approved to help with depressive symptoms in adults with major depressive disorder who are experiencing acute suicidal thoughts, used together with an oral antidepressant.
Spravato at Thrive Brain and Mind is overseen directly by John J. Aziz, MD, FAPA, board-certified by the American Board of Psychiatry and Neurology (ABPN) in Psychiatry and in Consultation-Liaison Psychiatry (Psychosomatic Psychiatry), the American Board of Addiction Medicine (ABAM), and the American Society of Clinical Psychopharmacology (ASCP), not handed off to a technician. Interventional psychiatry is all we do.
Q: Is Spravato covered by insurance near me in Columbus?
A: Yes. As a REMS-certified center near Columbus, we accept most insurance including Medicare for Spravato esketamine. Coverage requires treatment-resistant depression – tried 2+ antidepressants. We handle all prior authorization.
Q: Do you offer Spravato treatment in Logan, Ohio?
A: Evaluations available via telehealth for Logan, Lancaster and Athens. In-person Spravato treatment is at our advanced Powell center 15 minutes from Columbus with monitoring suite.
Most antidepressants act on serotonin and can take weeks to work. Spravato acts on glutamate, a different brain pathway, which is why it may help when other medications haven’t and why some people notice change in as little as 24 hours.
They’re related but not identical. Esketamine is a purified component of ketamine, FDA-approved specifically for treatment-resistant depression and given as a nasal spray in a certified setting.
Yes. Because Spravato is provided through the FDA’s REMS program, every dose is self-administered in our office and followed by about two hours of monitoring. You’ll arrange a ride home.
Everyone responds differently, but some people experience improvement within 24 hours. Your psychiatrist tracks your response and adjusts your plan.
Many commercial and Medicare plans cover Spravato for treatment-resistant depression, though coverage and prior-authorization rules vary. Our team helps verify your benefits before you start.
Reach out and our team will help you understand your options and whether this treatment is a fit.
No pressure — just a conversation.
Searching for Spravato near me in Columbus? Thrive Brain and Mind is a REMS-certified Spravato treatment center 15 minutes from Columbus in Powell, OH. We are one of few centers near Columbus offering FDA-approved esketamine nasal spray for treatment-resistant depression. Many patients from Columbus, Dublin, Worthington and Delaware choose us for physician-led care by Dr. Aziz. Most insurance including Medicare covers Spravato when criteria are met. Arrange a ride home after each 2-hour monitored session.
We offer telehealth evaluations throughout Ohio, including Logan, Lancaster, Athens and Hocking County, with in-clinic appointments available in Logan. Advanced in-person treatments including Spravato and MagStim TMS Therapy are provided at our Powell center, 15 minutes from Columbus.
Important safety information: Spravato® (esketamine) is a Schedule III controlled substance administered only in a certified healthcare setting under the FDA’s REMS program. It can cause sedation, dissociation, and increases in blood pressure, and is not appropriate for everyone. Do not drive or operate machinery until the next day after restful sleep. This page is educational and not a substitute for a medical evaluation.
