Physician-supervised ketamine injection therapy offers a fast-acting option for treatment-resistant depression, severe anxiety, and PTSD — delivered and monitored by a psychiatrist, with a plan built around you.
For decades ketamine has been used safely in medicine as an anesthetic. More recently, at carefully controlled sub-anesthetic doses, it’s become one of the most promising rapid-acting options for depression that hasn’t responded to other treatments — often easing symptoms far faster than traditional antidepressants.
Ketamine works on the brain’s glutamate system, helping restore the neural connections that chronic depression erodes. At Thrive Brain and Mind, your injections are planned, delivered, and monitored by a psychiatrist, with a treatment plan built around your history and goals.
Important: Ketamine injection for depression, anxiety and PTSD is an off-label, non-FDA-approved use of an FDA-approved anesthetic medication. It is not FDA-approved to treat depression — only Spravato is FDA-approved for treatment-resistant depression. This is a self-pay treatment not covered by insurance.[esketamine]
Your psychiatrist reviews your history, current medications, medical records and goals to decide whether ketamine is a safe and clinically appropriate option.
Your injection takes place in a calm, private setting in our Powell office where you are monitored throughout by medical staff. Many people describe the experience as floaty and dreamlike; our team is with you the whole time.
You'll rest until you are ready and arrange a ride home — you cannot drive after ketamine. Your psychiatrist tracks your response and adjusts the plan session to session.
Generally considered for adults whose symptoms haven’t responded to standard treatment and who are looking for a faster-acting option under close medical supervision.
Ketamine at Thrive Brain and Mind is overseen directly by John J. Aziz, MD, FAPA, board-certified by the American Board of Psychiatry and Neurology [ABPN] in Psychiatry and in Consultation-Liaison Psychiatry, the American Board of Addiction Medicine [ABAM], and the American Society of Clinical Psychopharmacology [ASCP], not a wellness clinic without psychiatric depth.
What’s the difference between ketamine and Spravato?
Spravato [esketamine nasal spray] is FDA-approved for treatment-resistant depression and is typically covered by insurance including Medicare at a REMS-certified center. Ketamine injection is an off-label use of generic ketamine, is self-pay, and is offered when Spravato or TMS are not suitable or after evaluation.
How quickly does ketamine work?
Some patients report improvement within hours to days, but response varies and is not guaranteed. Benefits may be temporary and require maintenance and coordination with ongoing psychiatric care.
Is ketamine therapy safe?
When administered in a medically supervised setting with monitoring of blood pressure, oxygen and mental status, ketamine has a known safety profile. It can cause temporary dissociation, changes in perception, nausea, and increases in blood pressure and is not appropriate for everyone with certain medical or psychiatric conditions.
Will I be sedated or unconscious?
No, you remain awake. Doses used for depression are sub-anesthetic, much lower than anesthesia doses, but you will need a ride home and cannot drive until the next day after restful sleep.
Spravato (esketamine) is FDA-approved specifically for treatment-resistant depression. Ketamine is used off-label and can be tailored more flexibly. Both are rapid-acting and physician-supervised.
Many people notice a shift within hours to a few days — much faster than traditional antidepressants. Responses vary and are tracked closely.
Under medical supervision it has a well-established safety profile. It can temporarily affect perception, blood pressure, and alertness, so every session is monitored and you’ll arrange a ride home. A full evaluation comes first.
Treatment-resistant depression, severe anxiety, and PTSD symptoms in adults who haven’t responded to standard treatment.
No. At the doses used you remain conscious. Many people describe a floaty, dreamlike feeling; our team is present throughout.
Reach out and our team will help you understand your options and whether this treatment is a fit.
No pressure — just a conversation.
Searching for ketamine therapy near me in Columbus, Ohio? Thrive Brain and Mind offers physician-supervised ketamine injection therapy in Powell, 15 minutes from downtown Columbus with free parking and easy access from Dublin, Worthington, Hilliard, Lewis Center and Delaware. All ketamine therapy is delivered and monitored directly by Dr. John J. Aziz, quadruple board-certified psychiatrist, not a wellness clinic. Ketamine for depression is off-label and self-pay — we also offer FDA-approved and insurance-covered options including Spravato and MagStim TMS Therapy when clinically appropriate.
We offer psychiatric evaluations via telehealth throughout Ohio, including Logan, Lancaster, Athens and Hocking County, with in-clinic appointments available in Logan at 61 N. Orchard St. Advanced interventional treatments including ketamine therapy, Spravato and TMS are provided at our Powell center at 3785 Attucks Dr, Powell, OH 43065, 15 minutes from Columbus.
Important safety information: Ketamine used for depression, anxiety, and PTSD is an off-label, non-FDA-approved use and is not appropriate for everyone. It can cause temporary dissociation, changes in perception, nausea, increases in blood pressure and changes in alertness. Treatment is always medically supervised in our Powell office and you will need a ride home. Do not drive or operate machinery until the next day after restful sleep. This page is educational and not medical advice.
